Mounjaro (tirzepatide), an injectable prescription medicine, is indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus. Limitations of Use: Mounjaro has not been studied in patients with a history of pancreatitis. Mounjaro is not indicated for use in patients with type 1 diabetes mellitus.
Like all medicines, this medicine can cause side effects, although not everybody gets them.
Serious side effects
Uncommon (may affect up to 1 in 100 people)
– Inflamed pancreas (acute pancreatitis) which could cause severe pain in the stomach and back
which does not go away. You should see a doctor immediately if you experience such
symptoms.
Rare (may affect up to 1 in 1 000 people)
– Severe allergic reactions (e.g. anaphylactic reaction, angioedema). You should get immediate
medical help and inform your doctor if you experience symptoms such as breathing problems,
rapid swelling of the lips, tongue and/or throat with difficulty swallowing and a fast heartbeat.
Other side effects
Very common (may affect more than 1 in 10 people)
– Low blood sugar (hypoglycaemia) when tirzepatide is used for the treatment of type 2 diabetes
with medicines that contain a sulphonylurea and/or insulin. If you are using a sulphonylurea or
insulin, the dose may need to be lowered while you use tirzepatide (see section 2, ‘Warnings
and precautions’). Symptoms of low blood sugar may include headache, drowsiness, weakness,
dizziness, feeling hungry, confusion, irritability, fast heartbeat and sweating. Your doctor
should tell you how to treat low blood sugar.
– Feeling sick (nausea) *
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– Diarrhoea*
– Being sick (vomiting) – this usually goes away over time**
– Constipation**. *
These side effects are usually not severe. They are most common when first starting tirzepatide but
decrease over time in most patients.
**Constipation and vomiting are very common when used for weight management, but common when
used for type 2 diabetes.
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